Osnovni principi farmakogenetičkog testiranja u onkologiji

Introduction: Precision medicine is an approach that considers genetics, environment
and lifestyle factors when prevent and treat diff erent diseases. The important part
of precision medicine is pharmacogeneticss, a branch of clinical pharmacology that
analyzes how genetic makeup aff ects the response to the drugs.
Methods: Since oncology is a fi eld of particular interest in precision medicine, this
article summarizes the basic principles of pharmacogenetics testing in cancer treatment.
Topic: The following topics have been discussed: Samples for pharmacogenetics testing (peripheral blood, tumor biopsy, liquid biopsy), methods in pharmacogenetics
testing (conventional hotspot methods and comprehensive genome profi ling), comprehensive genome profi ling (CGP) in clinical settings and oncology therapy in Serbia
that depends on genetic testing.