Aqueous Humor

Abstract

The eye is a double organ which is responsible for receiving information from the outside world and transforming it into electrical impulses, so they could get to the brain. Its principal function is to create vision. To be able to do that, it needs proper functioning of all of it’s parts. Besides the well know parts of the eye, such as cornea or lens, the eye contains many others which have an important function. One of those is the aqueous humor, a transparent fluid in the front chamber of the eye. The regulation and secretion of aqueous humor and it’s flow,  are physiologically significant processes for the eye. Besides that, the composition of the aquous humor is also important. This specific article is dealing with the proteomics of the aqueous humor, different proteins and enzymes disscovered in previous studies and those disscovered here for the first time. Incredible 763 proteins were found to circulate through the aqueous humor, 386 identified for the first time in this part of the eye. The results of this study will serve as a great baseline for other studies, whether on the aqueous humor itself or diseases in relation with it.

1. INTRODUCTION

After the brain, eyes are the most complex organ. One eye is composed of over 2 milion of working parts, but only 1/6 of it is exposed and visible from the outside. The eye is a small organ, which does not change it’s dimensions from birth until death, and it is there to convert light into electrical impulses. (Lamb, 2011)

The human eye is a double organ which is working on a principle similar to cameras. The transparent front of the eye is breaking the beams of light, projecting a smaller and inverted image on the photosensitive retina where the specialized nerve cells perform conversion into electrical nerve impulses. (Lamb, 2011)

The eye is the most important human sense because it receives 80% of all information from the environment, allows conscious perception of light, recognition of colors and depth perception. (McBride, 2010) In the area of the eye are a number of morphological and functional systems: optical, accommodative, the system of external eye muscles, photoreceptive, nervous system, the system for creating and circulating aqueous humor, cardiovascular, eye protective apparatus and system for maintaining the size and shape of the eye. The main role in keeping the shape of the eye and provision of nutrients has the aqueous humor, the central theme of this work. In this study, Krishna R.Murthy et al. (2015) took aqueous humor samples from different patients, processed further to different fractionation strategies and did an analysis by mass spectrometry. The results were more than satisfactory with 386 novel proteins identified in the human aqueous humor.