Visoka zdravstveno – sanitarna škola
strukovnih studija “Visan”, Beograd
Predmet: Farmakologija
Hipnotici i barbiturati
Seminarski rad
Mentor: Student:
Prof. dr Petrović Bojana Nataša Veljković 123-II/2014
U Beogradu ,
decembar.2014
______________________________________ 2 ____________________________________
Sadržaj:
I.Uvod----------------------------------------------------------------------------------------------3
IInikacije za primenu hipnotika ----------------------------------------------------------- 3
II a) BENZODIAZIPINI----------------------------------------------------------------------3
II b) Farmakološka dejstva-------------------------------------------------------------------4
II e) Farmakokinetika-----------------------------------------------------------------------4
II.1
kratko dejstvo
(manje od 5h) -------------------------------------------------------------4
II.2
srednje dejstvo
(5-24h)---------------------------------------------------------------------4
II.3 dugo dejstvo
(preko 24h) ------------------------------------------------------------------5
III . BARBITURATI---------------------------------------------------------------------------5
Istorijat---------------------------------------------------------------------------------------------5
Hemijska struktura------------------------------------------------------------------------------5
Mehanizam dejstva------------------------------------------------------------------------------5
Tolerancija-----------------------------------------------------------------------------------------6
Farmakokinetika---------------------------------------------------------------------------------6
Podela barbiturate-------------------------------------------------------------------------------7
1.ultrakratko delujući do 1h----------------------------------------------------------------------7
2. kratko delujući do 6h--------------------------------------------------------------------------7
3. srednje delujući do 10h-------------------------------------------------------------------------7
4. dugo delujući – do 24h-------------------------------------------------------------------------8
Toksikološke karakteristike barbiturate----------------------------------------------------8
Metabolizam barbiturate------------------------------------------------------------------------8
Eliminacija barbiturate--------------------------------------------------------------------------8
Mehanizam delovanja----------------------------------------------------------------------------9
Mehanizam toksičnosti---------------------------------------------------------------------------9
Lek/Otrov------------------------------------------------------------------------------------------9
Simptomi trovanja-------------------------------------------------------------------------------9
Sestrinske procedure kod trovane osobe----------------------------------------------------9
Toksikološki značaj------------------------------------------------------------------------------10
IV Način primene Barbiturata--------------------------------------------------------------10
V Neželjene pojave------------------------------------------------------------------------------10
VI Zaključak-------------------------------------------------------------------------------------10
VII Literatura-----------------------------------------------------------------------------------11
________________________________________________________________________
Hipnotici i barbiturati
-
Nataša Veljković
______________________________________ 3 ____________________________________
